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Article

Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia.

Blood - 4 Mar 2021

Song Lili, Yu Bo, Yang Yi, Liang Jianwei, Zhang Yingwen, Ding Lixia, Wang Tianyi, Wan Xinyu, Yang Xiaomin, Tang Jingyan, Wang Shengyue, Li Benshang, Li Yanxin, Feng Haizhong

Abstract excerpt

Leukemogenesis is characterized by chromosomal rearrangements with additional molecular disruptions, yet the cooperative mechanisms are still unclear. Using whole-exome sequencing of a pair of monozygotic twins who were discordant for childhood acute lymphoblastic leukemia (ALL) with ETV6-RUNX1 (E/R) gene fusion successively after birth, we identified the R209C mutation of G protein subunit α o1 (GNAO1) as a new...

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PMID: 32898863
DOI: 10.1182/blood.2020005622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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