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Novel LAMC2 fusion protein has tumor‐promoting properties in ovarian carcinoma

24 Oct 2021

Abstract excerpt

Laminins are heterotrimeric ECM proteins composed of α, β, and γ chains. The γ2 chain (Lm-γ2) is a frequently expressed monomer and its expression is closely associated with cancer progression. Laminin-γ2 contains an epidermal growth factor (EGF)-like domain in its domain III (DIII or LEb). Matrix metalloproteinases can cleave off the DIII region of Lm-γ2 that retains the ligand activity for EGF receptor (EGFR)....

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PMID: 34689384
DOI: 10.1111/cas.15149

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