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Article

Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition.

Cancer letters - 10 Jul 2015

Zhu Lin-Yan, Zhang Wen-Ming, Yang Xiao-Mei, Cui Lining, Li Jun, Zhang Yan-Li, Wang Ya-Hui, Ao Jun-Ping, Ma Ming-Ze, Lu Huan, Ren Yuan, Xu Shao-Hua, Yang Guang-Dong, Song Wei-Wei, Wang Jing-Hao, Zhang Xiao-Dan, Zhang Rong, Zhang Zhi-Gang

Abstract excerpt

Ovarian cancer remains the disease with the highest associated mortality rate of gynecologic malignancy due to cancer metastasis. Rearrangement of actin cytoskeleton by cytoskeleton protein plays a critical role in tumor cell metastasis. MICAL-L2, a member of MICAL family, can interact with actin-binding proteins, regulate actin cross-linking and coordinate the assembly of adherens junctions and tight junctions....

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PMID: 25864591
DOI: 10.1016/j.canlet.2015.04.002

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MET

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