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Laminin γ2–mediating T cell exclusion attenuates response to anti–PD-1 therapy

3 Feb 2021

Abstract excerpt

PD-1/PD-L1 blockade therapies provide notable clinical benefits for patients with advanced cancers, but the factors influencing the effectiveness of the treatment remain incompletely cataloged. Here, the up-regulation of laminin γ2 (Ln-γ2) predicted the attenuated efficacy of anti-PD-1 drugs and was associated with unfavorable outcomes in patients with lung cancer or esophageal cancer. Furthermore, Ln-γ2 was...

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PMID: 33536206
DOI: 10.1126/sciadv.abc8346

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