Article

LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer

2023-05-04

Abstract excerpt

<title>Abstract</title> <p>The epidermal growth factor receptor (EGFR) is one of the first and most prominent driver genes known to promote malignant lung cancer. Investigating regulatory mechanisms beyond ligand-receptor binding, phosphorylation, and receptor kinase activation as means of EGFR signaling activation is important for improving EGFR-targeted therapy. Here, we report that Laminin-5γ-2 (LAMC2) retaine...

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Literature Corpus work: c8f072b7-c46c-5c15-9006-6c2a42edbfeb
DOI: 10.21203/rs.3.rs-2882748/v1

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