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Article

Laminin-γ2-NR6A1 Fusion Protein Promotes Metastatic Potential in Non-Small-Cell Lung Carcinoma Cells without Epidermal Growth Factor Receptor Mutation.

The American journal of pathology - 1 Jul 2025

Kaneko Ryo, Kishimoto Yuri, Ishikawa Ozora, Funahashi Nobuaki, Koshikawa Naohiko

Abstract excerpt

Laminin-γ2 fusion gene (Lm-γ2F), formed by translocation between LAMC2 and NR6A1, functions as an epidermal growth factor receptor (EGFR) ligand. However, its expression and impact on cancers beyond the initially studied contexts remain unclear. This study focused on Lm-γ2F protein secretion and its role in non-small-cell lung carcinoma (NSCLC), where EGFR signaling plays a pivotal role in malignancy progression....

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Source

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Identifiers

PMID: 40252971
DOI: 10.1016/j.ajpath.2025.03.006
PMCID: PMC12264550

Genes

EGFR
NR6A1
LAMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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