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Article

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum.

Nature structural & molecular biology - 11 Sept 2011

Greenblatt Ethan J, Olzmann James A, Kopito Ron R

Abstract excerpt

The degradation of misfolded secretory proteins is ultimately mediated by the ubiquitin-proteasome system in the cytoplasm, therefore endoplasmic reticulum-associated degradation (ERAD) substrates must be dislocated across the ER membrane through a process driven by the AAA ATPase p97/VCP. Derlin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21909096
DOI: 10.1038/nsmb.2111
PMCID: PMC3196324

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21909096-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum.PMID 21909096Read ↗

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.Semantic proximity Read ↗

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.Semantic proximity Read ↗

The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.Semantic proximity Read ↗

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.Semantic proximity Read ↗

Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.Semantic proximity Read ↗

Derlin-dependent accumulation of integral membrane proteins at cell surfaces.Semantic proximity Read ↗

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.Semantic proximity Read ↗

Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis.Semantic proximity Read ↗

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core ComplexSemantic proximity Read ↗

The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.Semantic proximity Read ↗

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases.Semantic proximity Read ↗

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