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Article

Imbalance between genomic gain and loss identifies high-risk neuroblastoma patients with worse outcomes.

Neoplasia (New York, N.Y.) - 1 Jan 2021

Fernández-Blanco Beatriz, Berbegall Ana Pilar, Martin-Vañó Susana, Castel Victoria, Navarro Samuel, Noguera Rosa

Abstract excerpt

Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated 3 genomic instability indexes for primary tumor SNP array profiles from 127 HR-NB patients: (1) Copy number aberration burden (%gainslength+%losseslength), (2) copy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33190090
DOI: 10.1016/j.neo.2020.11.001
PMCID: PMC7674617

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