Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors.

Oncogene - 17 Mar 2016

Berbegall A P, Villamón E, Piqueras M, Tadeo I, Djos A, Ambros P F, Martinsson T, Ambros I M, Cañete A, Castel V, Navarro S, Noguera R

Abstract excerpt

Intratumoral heterogeneous MYCN amplification (hetMNA) is an unusual event in neuroblastoma with unascertained biological and clinical implications. Diagnosis is based on the detection of MYCN amplification surrounded by non-amplified tumor cells by fluorescence in situ hybridization (FISH). To better define the genetic features of hetMNA tumors, we studied the Spanish cohort of neuroblastic tumors by FISH and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 1
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Chromosomes, Human, Pair 2

Share to Gene Dosage

Share to N-Myc Proto-Oncogene Protein

Share to Neuroblastoma

Share to Oncogene Proteins

Source

Identifiers

PMID: 26119945
DOI: 10.1038/onc.2015.200

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors.PMID 26119945Read ↗

The genetic tumor background is an important determinant for heterogeneous MYCN-amplified neuroblastoma.Semantic proximity Read ↗

Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma StudySemantic proximity Read ↗

Intra-Tumour Genetic Heterogeneity and Prognosis in High-Risk NeuroblastomaSemantic proximity Read ↗

Genetic instability and intratumoral heterogeneity in neuroblastoma with MYCN amplification plus 11q deletion.Semantic proximity Read ↗

Heterogeneity of <i>MYCN</i> amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasisSemantic proximity Read ↗

Association of heterogeneous MYCN amplification with clinical features, biological characteristics and outcomes in neuroblastoma: A report from the Children's Oncology GroupSemantic proximity Read ↗

Heterogeneity of the MYCN Oncogene in NeuroblastomaSemantic proximity Read ↗

Characterization of amplicons in neuroblastoma: high-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes.Semantic proximity Read ↗

Imbalance between genomic gain and loss identifies high-risk neuroblastoma patients with worse outcomes.Semantic proximity Read ↗

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset.Semantic proximity Read ↗

Application of the FISH method and high-density SNP arrays to assess genetic changes in neuroblastoma-research by one institute.Semantic proximity Read ↗

Identification of patient subgroups with markedly disparate rates of <i>MYCN</i> amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group projectSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.