Article

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

2020-06-29

Abstract excerpt

The BTB-Kelch protein KLHL3 is a Cullin3-dependent E3 ligase that mediates the ubiquitin-dependent degradation of kinases WNK1-4 to control blood pressure and cell volume. A crystal structure of KLHL3 has defined its binding to an acidic degron motif containing a PXXP sequence that is strictly conserved in WNK1, WNK2 and WNK4. Mutations in the second proline abrograte the interaction causing the hypertension syndr...

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Literature Corpus work: 0ce98909-aec2-5680-8d1b-9bf59aa0d561
DOI: 10.1101/2020.06.29.178285

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