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A review of JAK–STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition

16 Oct 2021

Abstract excerpt

Spondyloarthritis (SpA) comprises a group of chronic inflammatory diseases with overlapping clinical, genetic and pathophysiological features including back pain, peripheral arthritis, psoriasis, enthesitis and dactylitis. Several cytokines are involved in the pathogenesis of SpA, variously contributing to each clinical manifestation. Many SpA-associated cytokines, including IL-23, IL-17, IL-6, type I/II...

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PMID: 34668515
DOI: 10.1093/rheumatology/keab740

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