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Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.

1 Jan 2000

Abstract excerpt

Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated production of these mediators. Over the past decade tremendous strides have been made in clarifying how cytokines transmit signals via pathways using the Janus kinase (Jak) protein tyrosine kinases and the...

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PMID: 11094415
DOI: 10.1186/ar66

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