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Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors

19 Dec 2019

Abstract excerpt

Cytokines can trigger multiple signalling pathways, including Janus tyrosine kinases [JAK] and signal transducers and activators of transcription [STATS] pathways. JAKs are cytoplasmic proteins that, following the binding of cytokines to their receptors, transduce the signal by phosphorylating STAT proteins which enter the nuclei and rapidly target gene promoters to regulate gene transcription. Due to the...

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PMID: 32083640
DOI: 10.1093/ecco-jcc/jjz206

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