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Article

An insight into JAK-STAT signalling in dermatology

13 May 2014

Abstract excerpt

Many emerging studies have implicated the Janus kinase/signal transducer and activator of transcription (JAK-STAT) cytokine signalling mechanism in disease pathogenesis. This signalling pathway is involved in haematopoiesis and immune development. Mutations in genes regulating JAK-STAT signalling can cause common inflammatory disorders and myeloproliferative disorders. JAK and STAT inhibitors are new management...

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PMID: 24825142
DOI: 10.1111/ced.12273

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