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Article

IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong?

18 Feb 2021

Abstract excerpt

Axial spondyloarthritis is a prevalent form of chronic arthritis which is related to psoriatic arthritis and skin psoriasis. TNF and IL-17A as well as IL-17F are key cytokines contributing to the pathobiology of this disease, as evidence by the therapeutic efficacy of inhibition of these factors. Despite the evidence that IL-23 acts as an upstream driver of Th17 cells, the T lymphocytes producing IL-17, and that...

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Identifiers

PMID: 33679714
DOI: 10.3389/fimmu.2020.623874

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