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Article

JAK/STAT as a Potential Therapeutic Target for Osteolytic Diseases

17 Jun 2023

Abstract excerpt

Several cytokines with major biological functions in inflammatory diseases exert their functions through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signal transduction pathway. JAKs phosphorylate the cytoplasmic domain of the receptor, inducing the activation of its substrates, mainly the proteins known as STATs. STATs bind to these phosphorylated tyrosine residues and...

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PMID: 37373437
DOI: 10.3390/ijms241210290

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