Article
Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer-promoter interaction.
Carcinogenesis - 12 Nov 2021
Wang Haoxue, Yang Beifang, Cai Xiaomin, Cheng Xiang, Shen Na, Liu Li, Li Jiaoyuan, Wang Ying, He Heng, Ying Pingting, Li Bin, Lu Zequn, Yang Nan, Wang Xiaoyang, Zhang Fuwei, Li Yanmin, Wang Wenzhuo, Ning Caibo, Zhu Ying, Chang Jiang, Miao Xiaoping, Tian Jianbo, Zhong Rong
Abstract excerpt
Substantial evidence highlighted the critical role of long non-coding RNAs (lncRNA) in driving hepatocarcinogenesis. We hypothesized that functional variants in genome-wide association studies (GWASs) associated loci might alter the expression levels of lncRNAs and contribute to the development of hepatocellular carcinoma (HCC). Here, we prioritized potentially cis-expression quantitative trait loci-based single...
Topics
- Antisense Elements (Genetics)
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Enhancer Elements, Genetic
- HLA-DQ beta-Chains
- Humans
- Liver Neoplasms
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic