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Article

A novel posttranslational modification of histone, H3 S-sulfhydration, is down-regulated in asthenozoospermic sperm.

Journal of assisted reproduction and genetics - 1 Dec 2021

Qi Qi, Pan Hongjie, Jiang Ning, Zhang Meixin, Sun Shenfei, Wan Xiaofeng, Zhang Fangxi, Zhang Lingling, Diao Hua, Wang Jian, Li Runsheng

Abstract excerpt

Oxidative stress is one of the major causes leading to male infertility including asthenozoospermia. Hydrogen sulfide (H2S) has been widely recognized to be a potent antioxidant whose role is partially implemented by protein S-sulfhydration. However, protein S-sulfhydration has not been reported in germ cells. Therefore, we investigated whether asthenozoospermia could be associated with sperm protein...

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Identifiers

PMID: 34664184
DOI: 10.1007/s10815-021-02314-x
PMCID: PMC8666411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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