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Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility

18 Dec 2019

Abstract excerpt

STUDY QUESTION: Does lysine 2-hydroxyisobutyrylation, a newly identified protein posttranslational modification (PTM), occur in human sperm and affect human sperm function? SUMMARY ANSWER: Lysine 2-hydroxyisobutyrylation mainly occurs in human sperm tail proteins, and excessive lysine 2-hydroxyisobutyrylation affects human sperm motility. WHAT IS KNOWN ALREADY: PTM is regarded as an important pathway in...

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PMID: 32142584
DOI: 10.1093/humrep/dez296

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