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Article

Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2022

Griffith Jessica I, Kim Minjee, Bruce Daniel J, Peterson Cristina D, Kitto Kelley F, Mohammad Afroz S, Rathi Sneha, Fairbanks Carolyn A, Wilcox George L, Elmquist William F

Abstract excerpt

Novel combinations of specific opioid agonists like loperamide and oxymorphindole targeting the µ- and δ-opioid receptors, respectively, have shown increased potency with minimized opioid-associated risks. However, whether their interaction is pharmacokinetic or pharmacodynamic in nature has not been determined. This study quantitatively determined whether these drugs have a pharmacokinetic interaction that...

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Identifiers

PMID: 34663676
DOI: 10.1124/jpet.121.000821
PMCID: PMC8969136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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