Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers.

doi:10.1007/s00228-014-1788-5

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Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers.

European journal of clinical pharmacology - 1 Feb 2015

Atkinson Hartley C, Stanescu Ioana, Salem Isam I, Potts Amanda L, Anderson Brian J

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PURPOSE: Over-the-counter combinations containing acetaminophen and phenylephrine for treatment of the common cold and influenza are widespread, but there are few data about pharmacokinetics of these two drugs used in combination. We aimed to investigate pharmacokinetic interactions between acetaminophen and phenylephrine. METHODS: A series of four randomised, open-label, crossover studies investigating...

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Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers.

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