Article
Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2015
Myers Michael J, Martinez Marilyn, Li Hui, Qiu Junshan, Troutman Lisa, Sharkey Michele, Yancy Haile F
Abstract excerpt
Thirty-three Collies (14 male and 19 female) were used in a dose-escalation study to determine the impact of ABCB1 genotype on loperamide pharmacokinetics (PK) and pharmacodynamics (PD). Loperamide was orally administered in four ascending doses (0.01, 0.05, 0.1, or 0.2 mg/kg) over a 4-wk period to fasted Collies. Comparisons were made within each dose to genotype, phenotype, and whether Collies received three...
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