Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2012

Zamek-Gliszczynski Maciej J, Bedwell David W, Bao Jing Q, Higgins J William

Abstract excerpt

Transporter gene knockout rats are practically advantageous over murine models for pharmacokinetic and excretion studies, but their phenotypic characterization is lacking. At present, relevant aspects of pharmacokinetics, metabolism, distribution, and excretion of transporter probes [P-glycoprotein (P-gp): loperamide and paclitaxel; breast cancer resistance protein (Bcrp): sulfasalazine; and multidrug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Biological Availability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biotransformation

Share to Fluoresceins

Share to Half-Life

Share to Metabolic Clearance Rate

Share to Paclitaxel

Share to Rats, Transgenic

Source

Identifiers

PMID: 22711747
DOI: 10.1124/dmd.112.046508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.PMID 22711747Read ↗

Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug DiscoverySemantic proximity Read ↗

Interaction of innovative small molecule drugs used for cancer therapy with drug transportersSemantic proximity Read ↗

Xenobiotic transporters: ascribing function from gene knockout and mutation studies.Semantic proximity Read ↗

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe.Semantic proximity Read ↗

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.Semantic proximity Read ↗

Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity.Semantic proximity Read ↗

Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice.Semantic proximity Read ↗

Utility of Mdr1-Gene Deficient Mice in Assessing the Impact of P-glycoprotein on Pharmacokinetics and Pharmacodynamics in Drug Discovery and DevelopmentSemantic proximity Read ↗

P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase InhibitorSemantic proximity Read ↗

Multidrug resistance and the role of P-glycoprotein knockout mice.Semantic proximity Read ↗

Overlapping Functions of ABC Transporters in Topotecan Disposition as Determined in Gene Knockout Mouse ModelsSemantic proximity Read ↗

Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interiorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.