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Article

Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice.

Pharmaceutical research - 1 Oct 2004

Kalvass J Cory, Graff Candace L, Pollack Gary M

Abstract excerpt

PURPOSE: A subpopulation of the CF-1 mouse strain (approximately 25%) lacks P-gp expression, and consequently, increased brain penetration of many substrates is observed in these animals. Mice lacking the mdr1a gene represent an important research tool to study the potential effects of P-gp on CNS substrate disposition. METHODS: Adult CF-1 mice were used in all experiments. Loperamide-induced antinociception was...

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PMID: 15553234
DOI: 10.1023/b:pham.0000045241.26925.8b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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