Article
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Journal of molecular biology - 19 Nov 2021
Saraon Punit, Snider Jamie, Schormann Wiebke, Rai Ankit, Radulovich Nikolina, Sánchez-Osuna Maria, Coulombe-Huntington Jasmin, Huard Caroline, Mohammed Mohammed, Lima-Fernandes Evelyne, Thériault Brigitte, Halabelian Levon, Chan Manuel, Joshi Dhananjay, Drecun Luka, Yao Zhong, Pathmanathan Shivanthy, Wong Victoria, Lyakisheva Anna, Aboualizadeh Farzaneh, Niu Li, Li Fengling, Kiyota Taira, Subramanian Ratheesh, Joseph Babu, Aman Ahmed, Prakesch Michael, Isaac Methvin, Mamai Ahmed, Poda Gennady, Vedadi Masoud, Marcellus Richard, Uehling David, Leighl Natasha, Sacher Adrian, Samaržija Miroslav, Jakopović Marko, Arrowsmith Cheryl, Tyers Mike, Tsao Ming-Sound, Andrews David, Al-Awar Rima, Stagljar Igor
Abstract excerpt
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR NSCLC, however, acquired resistance is a major issue, leading to disease relapse. Here, we characterize a small molecule, EMI66, an analog of a small molecule which we...
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