Article

Potentiation of EGFR mutant lung cancer treatment targeting replication stress

2025-04-18

Abstract excerpt

<h4>Background/Objectives</h4> Oncogene-targeted therapies against growth factor receptors are effective treatment options for driver mutation-positive non-small cell lung cancer (NSCLC). The third-generation EGFR-Tyrosine Kinase inhibitor (TKI) osimertinib, is a standard first-line therapy for patients with EGFR-mutated NSCLC cancer. Acquired resistance to osimertinib is a significant problem that limits surviva...

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Literature Corpus work: 8bab3d37-056e-52ce-af9e-2a61f7dfa7d8
DOI: 10.1101/2025.04.18.649510

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