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Article

SARS-CoV-2 competes with host mRNAs for efficient translation by maintaining the mutations favorable for translation initiation.

Journal of applied genetics - 1 Feb 2022

Zhang Yanping, Jin Xiaojie, Wang Haiyan, Miao Yaoyao, Yang Xiaoping, Jiang Wenqing, Yin Bin

Abstract excerpt

During SARS-CoV-2 proliferation, the translation of viral RNAs is usually the rate-limiting step. Understanding the molecular details of this step is beneficial for uncovering the origin and evolution of SARS-CoV-2 and even for controlling the pandemic. To date, it is unclear how SARS-CoV-2 competes with host mRNAs for ribosome binding and efficient translation. We retrieved the coding sequences of all human...

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Identifiers

PMID: 34655422
DOI: 10.1007/s13353-021-00665-w
PMCID: PMC8520108

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