Article
Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames.
Scientific reports - 23 Jul 2020
Wang Yong, Mao Jun-Ming, Wang Guang-Dong, Luo Zhi-Peng, Yang Liu, Yao Qin, Chen Ke-Ping
Abstract excerpt
The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG reduction in SARS-CoV-2 is achieved mainly through mutating C/G into A/T, and CG is the best target for mutation....
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