Article
Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects.
Cancer immunology, immunotherapy : CII - 1 Jun 2022
Pan Cheng, Fujiwara Yukio, Horlad Hasita, Iriki Toyohisa, Shiraishi Daisuke, Komohara Yoshihiro
Abstract excerpt
Tumor-associated macrophages (TAMs), especially the M2-like phenotype, promote tumor progression, making them candidate targets for anti-tumor therapy. We previously discovered a cyclic sulfur compound, Onionin A (ONA), which suppresses tumor progression by inhibiting the M2-polarization of TAMs. In the present study, we sought to find new candidate compounds possessing a stronger effect compared to ONA by...
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