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Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Feb 2021

Shen Huan, Sun Changquan Calvin, Kang Lichun, Tan Xiaoyue, Shi Peng, Wang Lingyu, Liu Ergang, Gong Junbo

Abstract excerpt

Macrophages are sentinels of the immune system, which are often hijacked by tumor cells to assist tumor growth and metastasis. Herein our results showed that low dose salinomycin (SAL) in the range of 10-50 nM could efficiently induce M1 macrophage polarization in a dose- and time- dependent manner in vitro, with 30 nM SAL being optimal to generate M1-type macrophages from RAW246.7 cells. In animal study,...

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PMID: 33176191
DOI: 10.1016/j.ejps.2020.105629

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