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Article

Polymorphism rs7521584 in miR‑429 is associated with the severity of atrophic gastritis in patients with Helicobacter pylori infection.

Molecular medicine reports - 1 Aug 2018

Otsuka Toshimi, Tahara Tomomitsu, Nakamura Masakatsu, Jing Wu, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Shibata Tomoyuki, Arisawa Tomiyasu

Abstract excerpt

The aim of the present study was to investigate an association of genetic polymorphism (rs7521584) located in miR‑200a‑200b‑429 cluster, which has tumor suppressor and pro‑inflammatory function, with the development of gastric mucosal atrophy and metaplasia as a pre‑malignant condition. Gastric mucosa samples were obtained from the antrum of 393 patients with no malignancies. The rs7521584 genotype was determined...

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Identifiers

PMID: 29956763
DOI: 10.3892/mmr.2018.9200

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