Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of rare coding variants of charged amino acid residues on the function of human organic anion transporting polypeptide 1B3 (SLCO1B3).

Biochemical and biophysical research communications - 11 Jun 2021

Liu Shuai, Peng Taotao, Wang Zhongmin, Li Ying, Zhang Hongjian, Gui Chunshan

Abstract excerpt

Human organic anion transporting polypeptide 1B3 (OATP1B3, gene symbol SLCO1B3) is a liver-specific uptake transporter. Its function was reported to be largely affected by some positively charged amino acid residues. However, so far the effect of naturally occurring genetic variants of charged residues on OATP1B3's function has not been explored yet. Therefore, in the present study nonsynonymous single nucleotide...

Topics

Join the communities discussing this publication.

Amino Acid Substitution
Biological Transport
Cells, Cultured
Liver
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Solute Carrier Organic Anion Transporter Family Member 1B3

Structure-Activity Relationship

Source

Identifiers

PMID: 33853029
DOI: 10.1016/j.bbrc.2021.03.169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of rare coding variants of charged amino acid residues on the function of human organic anion transporting polypeptide 1B3 (SLCO1B3).PMID 33853029Read ↗

Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).Semantic proximity Read ↗

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.Semantic proximity Read ↗

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.Semantic proximity Read ↗

Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.Semantic proximity Read ↗

Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population.Semantic proximity Read ↗

Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokineticsSemantic proximity Read ↗

Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3: genetic variability and haplotype analysis in white Canadians.Semantic proximity Read ↗

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).Semantic proximity Read ↗

Non-neutral nonsynonymous single nucleotide polymorphisms in human ABC transporters: the first comparison of six prediction methods.Semantic proximity Read ↗

In vitro characterization of SLCO2B1 genetic variants.Semantic proximity Read ↗

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.Semantic proximity Read ↗

Genetic variations of the SLCO1B1 gene in the Chinese, Malay and Indian populations of Singapore.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.