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H3K27M-mutant, hemispheric diffuse glioma in an adult patient with prolonged survival

1 Jan 2021

Abstract excerpt

The K27M mutation of the histone 3 (H3) isoforms has been identified as the main driver mutation of diffuse gliomas arising from the midline structures. This tumor predominantly affects children1 and to a lesser extent the adult population.2–4 Pediatric patients with H3K27M-mutant diffuse midline glioma (DMG) have a uniformly poor prognosis, with a median overall survival of 9 to 15 months,1 while the prognosis...

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PMID: 34647024
DOI: 10.1093/noajnl/vdab135

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