Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

1 Oct 2003

Abstract excerpt

Activation of naive T cells through the TCR and cytokine signals directs their differentiation into effector or memory subsets with different cytokine profiles. Here, we tested the flexibility of human Th1 or Th2 differentiation by forced expression of transcription factors T-bet and GATA-3. Ectopic expression of T-bet and GATA-3 in freshly isolated human T(N) cells resulted in their differentiation to a Th1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14500650
DOI: 10.4049/jimmunol.171.7.3542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell DifferentiationPMID 14500650Read ↗

Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice.Semantic proximity Read ↗

GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cellsSemantic proximity Read ↗

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 CellsSemantic proximity Read ↗

Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3Semantic proximity Read ↗

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fateSemantic proximity Read ↗

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiationSemantic proximity Read ↗

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid CellsSemantic proximity Read ↗

GATA-3 in Human T Cell Helper Type 2 DevelopmentSemantic proximity Read ↗

Human CCR6 <sup>+</sup> Th cells show both an extended stable gradient of Th17 activity and imprinted plasticitySemantic proximity Read ↗

Chromatin remodeling and T helper subset differentiation.Semantic proximity Read ↗

Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.Semantic proximity Read ↗

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.