Article
Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation.
Immunological reviews - 1 May 2010
Rutishauser Rachel L, Kaech Susan M
Abstract excerpt
SUMMARY: In response to acute infections or vaccines, naive antigen-specific CD8(+) T cells proliferate and differentiate into effector cytotoxic lymphocytes that acquire the ability to kill infected cells. While the majority of differentiated effector cells die after pathogen clearance, a small number evade terminal differentiation, downregulate active effector functions, and survive as long-lived, self-renewing...
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