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Article

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2011

Denton Alice E, Russ Brendan E, Doherty Peter C, Rao Sudha, Turner Stephen J

Abstract excerpt

Although the simultaneous engagement of multiple effector mechanisms is thought to characterize optimal CD8(+) T-cell immunity and facilitate pathogen clearance, the differentiation pathways leading to the acquisition and maintenance of such polyfunctional activity are not well understood. Division-dependent profiles of effector molecule expression for virus-specific T cells are analyzed here by using a...

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Share to CD8-Positive T-Lymphocytes
Share to Immunologic Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Lymphocyte Activation

Share to Protein Processing, Post-Translational

Share to RNA Polymerase II

Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 21876173
DOI: 10.1073/pnas.1112520108
PMCID: PMC3174616

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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