Article
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
Cell - 11 Nov 2021
Tal Nitzan, Morehouse Benjamin R, Millman Adi, Stokar-Avihail Avigail, Avraham Carmel, Fedorenko Taya, Yirmiya Erez, Herbst Ehud, Brandis Alexander, Mehlman Tevie, Oppenheimer-Shaanan Yaara, Keszei Alexander F A, Shao Sichen, Amitai Gil, Kranzusch Philip J, Sorek Rotem
Abstract excerpt
The cyclic pyrimidines 3',5'-cyclic cytidine monophosphate (cCMP) and 3',5'-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP), which are second messenger molecules with well-established regulatory roles across all domains of life, the...
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