Article
HLA-E circulating and genetic determinants in schizophrenia and bipolar disorder.
Scientific reports - 12 Oct 2021
Boukouaci Wahid, Lajnef Mohamed, Richard Jean-Romain, Wu Ching-Lien, Bouassida Jihène, Rafik Ismail, Foiselle Marianne, Straczek Céline, Mezouad Esma, Naamoune Soumia, Salah Sofiane, Bencharif Mohamed Amin, Ben Chaaben Arij, Barau Caroline, Le Corvoisier Philippe, Leboyer Marion, Tamouza Ryad
Abstract excerpt
Schizophrenia (SZ) and bipolar disorders (BD) are severe mental illnesses that lack reliable biomarkers to guide diagnosis and management. As immune dysregulation is associated with these disorders, we utilized the immunoregulatory functions of the natural killer cell inhibitory HLA-E locus to investigate the relationships between HLA-E genetic and expression diversities with SZ and BD risk and severity. Four...
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