Article
Paradoxical downregulation of HLA-A expression by IFNγ associated with schizophrenia and noncoding genes.
Immunobiology - 1 May 2013
Gu Songhai, Fellerhoff Barbara, Müller Norbert, Laumbacher Barbara, Wank Rudolf
Abstract excerpt
Neuronal MHC/HLA regulates the synapses of the central nervous system (CNS). The expression of MHC/HLA is, in turn, regulated by immune cytokines. We were therefore interested in the regulation of schizophrenia-associated HLA antigens, specifically their regulation of expression by interferons. We had previously observed a moderately increased frequency of HLA-A10 expression in schizophrenic patients. While...
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