Article
HLA-E allelic genotype correlates with HLA-E plasma levels and predicts early progression in chronic lymphocytic leukemia.
Cancer - 1 Mar 2017
Wagner Bettina, da Silva Nardi Fabiola, Schramm Sabine, Kraemer Thomas, Celik Alexander A, Dürig Jan, Horn Peter A, Dührsen Ulrich, Nückel Holger, Rebmann Vera
Abstract excerpt
BACKGROUND: Human leukocyte antigen-E (HLA-E) is a nonclassical major histocompatibility complex class I molecule that recently came into sharper focus as a putative marker of advanced tumor stages and disease progression. In solid tumors, increased HLA-E expression as well as elevated soluble HLA-E (sHLA-E) plasma levels are associated with a poor prognosis; however, a role for HLA-E in hematologic malignancies...
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