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Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

4 Dec 2012

Abstract excerpt

Epidemiological and genome-wide association studies of severe psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BD), suggest complex interactions between multiple genetic elements and environmental factors. The involvement of genetic elements such as Human Endogenous Retroviruses type 'W' family (HERV-W) has consistently been associated with SZ. HERV-W envelope gene (env) is activated by...

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PMID: 23212585
DOI: 10.1038/tp.2012.125

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