Article
Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer.
Nature communications - 12 Oct 2021
Ferreiro-Iglesias Aida, McKay James D, Brenner Nicole, Virani Shama, Lesseur Corina, Gaborieau Valerie, Ness Andy R, Hung Rayjean J, Liu Geoffrey, Diergaarde Brenda, Olshan Andrew F, Hayes Neil, Weissler Mark C, Schroeder Lea, Bender Noemi, Pawlita Michael, Thomas Steve, Pring Miranda, Dudding Tom, Kanterewicz Beatriz, Ferris Robert, Thomas Sera, Brhane Yonathan, Díez-Obrero Virginia, Milojevic Maja, Smith-Byrne Karl, Mariosa Daniela, Johansson Mattias J, Herrero Rolando, Boccia Stefania, Cadoni Gabriella, Lacko Martin, Holcátová Ivana, Ahrens Wolfgang, Lagiou Pagona, Lagiou Areti, Polesel Jerry, Simonato Lorenzo, Merletti Franco, Healy Claire M, Hansen Bo T, Nygård Mari, Conway David I, Wright Sylvia, Macfarlane Tatiana V, Robinson Max, Alemany Laia, Agudo Antonio, Znaor Ariana, Amos Christopher I, Waterboer Tim, Brennan Paul
Abstract excerpt
Although several oropharyngeal cancer (OPC) susceptibility loci have been identified, most previous studies lacked detailed information on human papillomavirus (HPV) status. We conduct a genome-wide analysis by HPV16 serology status in 4,002 oral cancer cases (OPC and oral cavity cancer (OCC)) and 5,256 controls. We detect four susceptibility loci pointing to a distinct genetic predisposition by HPV status. Our...
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