Article
A systematic investigation of the contribution of genetic variation within the MHC region to HPV seropositivity.
Human molecular genetics - 1 May 2015
Chen Dan, Gaborieau Valérie, Zhao Yao, Chabrier Amélie, Wang Huibo, Waterboer Tim, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Bencko Vladimir, Janout Vladimir, Foretova Lenka, Mates Ioan Nicolae, Szeszenia-Dabrowska Neonila, Boffetta Paolo, Pawlita Michael, Lathrop Mark, Gyllensten Ulf, Brennan Paul, McKay James D
Abstract excerpt
High-risk mucosal types of human papillomavirus (HPV) cause anogenital and oropharyngeal cancers, whereas cutaneous types (e.g. HPV8 and 77) are suspected to be involved in non-melanoma skin cancer. The antibody response to HPVs is a key determinant of protective immunity, but not all infected individuals seroconvert. Genetic variability of the host may have large impact on seroconversion. A previous genome-wide...
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