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Article

Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2006

Butcher Jonathan T, Tressel Sarah, Johnson Tiffany, Turner Debi, Sorescu George, Jo Hanjoong, Nerem Robert M

Abstract excerpt

OBJECTIVE: The similarities between valvular and vascular lesions suggest pathological initiation mediated through endothelium, but the role of hemodynamics in valvular endothelial biology is poorly understood. METHODS AND RESULTS: Monolayers of porcine aortic endothelial cells (PAECs) or porcine aortic valve endothelial cells (PAVECs) were exposed to 20 dyne/cm2 steady laminar shear stress for 48 hours, with...

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Identifiers

PMID: 16293796
DOI: 10.1161/01.ATV.0000196624.70507.0d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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