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A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19.

mBio - 26 Oct 2021

Chen Tao, Lin Yu-Xin, Zha Yan, Sun Ying, Tian Jinxiu, Yang Zhiying, Lin Shan-Wen, Yu Fuxun, Chen Zi-Sheng, Kuang Bo-Hua, Lei Jin-Ju, Nie Ying-Jie, Xu Yonghao, Tian Dong-Bo, Li Ying-Zi, Yang Bin, Xu Qiang, Yang Li, Zhong Nanshan, Zheng Meizhen, Li Yimin, Zhao Jincun, Zhang Xiang-Yan, Feng Lin

Abstract excerpt

Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its level strongly correlates with disease progression. To investigate whether variability in COVID-19 severity partially results from differential IL-6 expression, functional single-nucleotide polymorphisms (SNPs) of IL-6 were determined in Chinese COVID-19 patients with mild or severe illness. An Asian-common IL-6 haplotype defined by...

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PMID: 34634929
DOI: 10.1128/mBio.01372-21
PMCID: PMC8510538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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