Article
Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.
Viruses - 19 May 2023
Rodrigues Fabíola Brasil Barbosa, da Silva Rosilene, Santos Erika Ferreira Dos, de Brito Mioni Thieli Figueiredo Magalhães, da Silva Andréa Luciana Soares, de Meira Leite Mauro, Póvoa da Costa Flávia, de Nazaré do Socorro de Almeida Viana Maria, de Sarges Kevin Matheus Lima, Cantanhede Marcos Henrique Damasceno, Veríssimo Adriana de Oliveira Lameira, Carvalho Mayara da Silva, Henriques Daniele Freitas, Silva Carla Pinheiro da, Costa Igor Brasil, Nunes Juliana Abreu Lima, Costa Iran Barros, Viana Giselle Maria Rachid, Queiroz Maria Alice Freitas, Lima Sandra Souza, Lopes Jeferson da Costa, Torres Maria Karoliny da Silva, Vallinoto Izaura Maria Vieira Cayres, Bichara Carlos David Araújo, Vallinoto Antonio Carlos Rosário, Santos Eduardo José Melo Dos
Abstract excerpt
Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6....