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Article

Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity.

International journal of immunogenetics - 1 Feb 2023

Verma Shrikant, Verma Sushma, Khan Faizan Haider, Siddiqi Zeba, Raza Syed Tasleem, Abbas Mohammad, Mahdi Farzana

Abstract excerpt

Coronavirus disease-2019 (COVID-19) is pro-inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin-6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and associated with the severity in COVID-19 patients. The differential expression of IL6 cytokine in COVID-19 patients may be associated with the presence of single nucleotide...

Topics

Humans
Interleukin-6
Genetic Predisposition to Disease
COVID-19
Genotype
Polymorphism, Single Nucleotide
Gene Frequency

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36323530
DOI: 10.1111/iji.12605
PMCID: PMC9878250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-36323530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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