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Article

Impact of IL-6 rs1800795 and rs1800796 polymorphisms on clinical outcomes of COVID-19: a study on severity of disease in Turkish population.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2025

Cekin Nilgun, Akin Seyda, Pinarbasi Ergun, Doğan Okan Halef

Abstract excerpt

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is exacerbated by cytokine storms, leading to severe inflammation. Interleukin-6 (IL-6) plays a critical role in this process, and variations in its promoter may influence disease severity. This study aims to investigate the relationship between IL6 promoter polymorphisms rs1800795 (G > C) and rs1800796 (G > C)...

Topics

Humans
COVID-19
Turkey
Interleukin-6
Male
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Middle Aged

Severity of Illness Index

Adult

SARS-CoV-2

Genetic Predisposition to Disease

Aged

Promoter Regions, Genetic

Genotype

Alleles

Source

Identifiers

PMID: 39567384
DOI: 10.1007/s00335-024-10085-w

Genes

GC
IL6
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39567384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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