Article
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons.
Stem cell reports - 8 Sept 2020
Kumar Manoj, Acevedo-Cintrón Jesús, Jhaldiyal Aanishaa, Wang Hu, Andrabi Shaida A, Eacker Stephen, Karuppagounder Senthilkumar S, Brahmachari Saurav, Chen Rong, Kim Hyesoo, Ko Han Seok, Dawson Valina L, Dawson Ted M
Abstract excerpt
Mutations and loss of activity in PARKIN, an E3 ubiquitin ligase, play a role in the pathogenesis of Parkinson's disease (PD). PARKIN regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy) and mitochondrial biogenesis. Defects in mitophagy have been hypothesized to play a predominant role in the loss of dopamine (DA) neurons in PD. Here, we show that although there...
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