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Article

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife - 14 May 2020

Yang Chao, Siebert Jason R, Burns Robert, Zheng Yongwei, Mei Ao, Bonacci Benedetta, Wang Demin, Urrutia Raul A, Riese Matthew J, Rao Sridhar, Carlson Karen-Sue, Thakar Monica S, Malarkannan Subramaniam

Abstract excerpt

The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based on transcriptome, we identified five distinct NK cell clusters and define their relative developmental maturity in the bone marrow. Transcriptome-based...

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Identifiers

PMID: 32406817
DOI: 10.7554/eLife.51339
PMCID: PMC7255804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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